UCLA Lipidomics - Publications

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Chan AP, Czernuszewicz TJ, Lai RW, Jarrett KE, Lau A, Warshan A, Cheng AS, Steel ME, Schmidt HM, Larios J, Little I, Rubert GE, Brearley-Sholto MC, Mamouei Z, Pesner JK, Hamad CD, Francis KP, Bernthal NM, Redente EF, Magyar CE, French SW, Williams KJ, Tarling EJ, de Aguiar Vallim TQ. Intestinal lipase inhibition uncouples diet-induced obesity from MASH by remodeling the hepatic lipidome in mice. J Lipid Res. 2026 Jul 27:101112. doi: 10.1016/j.jlr.2026.101112. Epub ahead of print. PMID: 42508572.
Chan AP, Jarrett KE, Lai RW, Clifford BL, Williams KJ, Tarling EJ, de Aguiar Vallim TQ. A protocol for noninvasive quantification of dietary fat absorption in mice. STAR Protoc. 2026 Jun 25;7(3):104658. doi: 10.1016/j.xpro.2026.104658. Epub ahead of print. PMID: 42360884; PMCID: PMC13333356.
Dave A, Ng ESY, Jiang Z, Hu J, Tatang J, Paniagua A, Doeve J, Parikh S, Williams KJ, Stiles L, Radu RA. DGAT1-associated lipid-retinoid dysregulation correlates with metabolic impairment in the RPE of Stargardt disease. iScience. 2026 Jul 13;29(8):116727. doi: 10.1016/j.isci.2026.116727. PMID: 42519008; PMCID: PMC13382123.
Shay JES, Chi F, Tzouanas CN, Han S, Zhang X, Ten Hoeve J, Williams KJ, Neptun S, Sever T, Fuentes I, Bhatia SN, Calibasi-Kocal G, Vander Heiden MG, Shalek AK, Yilmaz ÖH. Ketogenic diet mediates intestinal tumorigenesis through lipids not ketones. Nature. 2026 Aug;656(8127):474-483. doi: 10.1038/s41586-026-10779-y. Epub 2026 Jul 15. PMID: 42457955.
Mnatsakanyan H, Sammarco A, Hewett A, Awwad R, Roumieh E, Pechdimaljian C, Cakici C, Spangler CM, Azar Y, Pradhan R, Su B, Williams KJ, Bensinger SJ, Badr CE. SCD1 and SCD5 modulate PARP-dependent DNA repair via fatty acid desaturation in glioblastoma. Cell Rep. 2026 Apr 13;45(4):117223. doi: 10.1016/j.celrep.2026.117223. Epub ahead of print. PMID: 41979920; PMCID: PMC13181748.
Mason EJ, Schraw JM, Woodhouse JP, Gramatges MM, Williams KJ, Chen B, Harrell MB, Taylor OA, Scheurer ME, Lupo PJ, Rabin KR, Yi JS, Huynh V, Mittelman SD, Orgel E, Brown A. Lipidomic profiles associated with treatment related hepatotoxicity in children with acute lymphoblastic leukemia. Support Care Cancer. 2026 Feb 17;34(3):209. doi: 10.1007/s00520-026-10414-6. PMID: 41699110; PMCID: PMC12909625.
Chan AP, Jarrett KE, Lai RW, Brearley-Sholto MC, Cheng AS, Taveras MO, Iwata AM, Steel ME, Lau A, Whang EC, Kennelly JP, Gao Y, Rubert GE, Schmidt HM, Smith EP, Su B, Williams KJ, Tarling EJ, de Aguiar Vallim TQ. Bile acids regulate lipid metabolism through selective actions on fatty acid absorption. Cell Metab. 2026 Feb 3;38(2):263-280.e10. doi: 10.1016/j.cmet.2025.11.010. Epub 2025 Dec 11. PMID: 41386220; PMCID: PMC12767720.
Aycinena JA, Tefera AE, Perea-Gil I, Holbrook-Smith D, Williams K, Shenwai R, Farshidfar F, Ryback B, Foppe K, Wu I, Zeng A, Van Pell M, Xu E, Woods J, Jones S, Hatter Y, Dee-Hoskins C, Madariaga J, Robinson K, Greer-Short A, Song X, Ivey KN, Priest J, Argast G, Hoey T, Driggers E, Yang ZJ. Maintenance of energy metabolism Is an integral part of plakophilin-2 and desmosome functions. JACC Basic Transl Sci. 2025 Dec;10(12):101428. doi: 10.1016/j.jacbts.2025.101428. PMID: 41432339; PMCID: PMC12861652.
Jeyachandran AV, Irudayam JI, Dubey S, Chakravarty N, Daskou M, Zaiss A, Garcia G, Konda B, Shah A, Venkatraman A, Su B, Wang C, Cui Q, Williams KJ, Srikanth S, Kumar A, Shi Y, Deb A, Damoiseaux R, Stripp BR, Ramaiah A, Arumugaswami V. Differential tropisms of old and new world hantaviruses influence virulence and developing host-directed antiviral candidates. PLoS Pathog. 2025 Aug 26;21(8):e1013401. doi: 10.1371/journal.ppat.1013401. PMID: 40857262; PMCID: PMC12380290.
Tol MJ, Shimanaka Y, Bedard AH, Sapia J, Cui L, Colaço-Gaspar M, Hofer P, Ferrari A, Qian K, Kennelly JP, Lee SD, Gao Y, Xiao X, Gao J, Mack JJ, Weston TA, Williams KJ, Su B, Pan C, Lusis AJ, Pike DP, Reed A, Milosevich N, Cravatt BF, Arita M, Young SG, Ford DA, Zechner R, Vanni S, Tontonoz P. Dietary control of peripheral adipose storage capacity through membrane lipid remodelling. Nat Metab. 2025 Jul;7(7):1424-1442. doi: 10.1038/s42255-025-01320-y. Epub 2025 Jun 27. PMID: 40579620.
Ross MG, Kavasery MP, Han G, Cervantes MK, Bora L, Williams KJ, Desai M. Imbalance of ω3 and ω6 Fatty Acids in Breast Milk of Overweight/Obese Women. Nutrients. 2025 Jun 28;17(13):2158. doi: 10.3390/nu17132158. PMID: 40647263; PMCID: PMC12252103.
Daly AE, Chang AB, Purbey PK, Williams KJ, Li S, Redelings BD, Yeh G, Wu Y, Pope SD, Venkatesh B, Li S, Nguyen K, Rodrigues J, Jorgensen K, Dasgupta A, Siggers T, Chen L, Smale ST. Stepwise neofunctionalization of the NF-κB family member Rel during vertebrate evolution. Nat Immunol. 2025 May;26(5):760-774. doi: 10.1038/s41590-025-02138-2. Epub 2025 Apr 30. PMID: 40307452; PMCID: PMC12043515.
Chan H, Li F, Dokoshi T, Cavagnero KJ, Li Q, Chen Y, Aguilera C, Nakatsuji T, Liu E, Indra A, Yang D, Valentina O, Numata T, Crown B, Li H, Williams KJ, Chiu IM, Bensinger SJ, Chen W, Gallo RL. Psychological stress increases skin infection through the action of TGFβ to suppress immune-acting fibroblasts. Sci Immunol. 2025 Apr 11;10(106):eads0519. doi: 10.1126/sciimmunol.ads0519. Epub 2025 Apr 11. PMID: 40215323; PMCID: PMC12183641.
Sammarco A, Guerra G, Eyme KM, Kennewick K, Qiao Y, El Hokayem J, Williams KJ, Su B, Cakici C, Mnatsakanyan H, Zappulli V, Bensinger SJ, Badr CE. Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast cancer brain metastasis mouse models. Commun Biol. 2025 Apr 4;8(1):562. doi: 10.1038/s42003-025-07977-1. PMID: 40185889; PMCID: PMC11971295.
Su B, Williams KJ. Analysis of the mammalian lipidome by DMS shotgun lipidomics. Methods Mol Biol. 2025;2855:357-372. doi: 10.1007/978-1-0716-4116-3_21. PMID: 39354318.
Hong SG, Kennelly JP, Williams KJ, Bensinger SJ, Mack JJ. Flow-mediated modulation of the endothelial cell lipidome. Front Physiol. 2024 Jul 24;15:1431847. doi: 10.3389/fphys.2024.1431847. PMID: 39119214; PMCID: PMC11307263.
York AG, Skadow MH, Oh J, Qu R, Zhou QD, Hsieh WY, Mowel WK, Brewer JR, Kaffe E, Williams KJ, Kluger Y, Smale ST, Crawford JM, Bensinger SJ, Flavell RA. IL-10 constrains sphingolipid metabolism to limit inflammation. Nature. 2024 Mar;627(8004):628-635. doi: 10.1038/s41586-024-07098-5. Epub 2024 Feb 21. PMID: 38383790; PMCID: PMC10954550.
Sulaiman D, Wu D, Black LP, Williams KJ, Graim K, Datta S, Reddy ST, Guirgis FW. Lipidomic changes in a novel sepsis outcome-based analysis reveals potent pro-inflammatory and pro-resolving signaling lipids. Clin Transl Sci. 2024 Mar;17(3):e13745. doi: 10.1111/cts.13745. PMID: 38488489; PMCID: PMC10941572.
Lee E, Williams KJ, McCarthy C, Bridges JP, Redente EF, de Aguiar Vallim TQ, Barrington RA, Wang T, Tarling EJ. Alveolar macrophage lipid burden correlates with clinical improvement in patients with pulmonary alveolar proteinosis. J Lipid Res. 2024 Feb;65(2):100496. doi: 10.1016/j.jlr.2024.100496. Epub 2024 Jan 6. PMID: 38185217; PMCID: PMC10844116.
Zhang S, Williams KJ, Verlande-Ferrero A, Chan AP, Su GB, Kershaw EE, Cox JE, Maschek JA, Shapira SN, Christofk HR, de Aguiar Vallim TQ, Masri S, Villanueva CJ. Acute activation of adipocyte lipolysis reveals dynamic lipid remodeling of the hepatic lipidome. J Lipid Res. 2024 Feb;65(2):100434. doi: 10.1016/j.jlr.2023.100434. Epub 2023 Aug 26. PMID: 37640283; PMCID: PMC10839691.
Ferrari A, Whang E, Xiao X, Kennelly JP, Romartinez-Alonso B, Mack JJ, Weston T, Chen K, Kim Y, Tol MJ, Bideyan L, Nguyen A, Gao Y, Cui L, Bedard AH, Sandhu J, Lee SD, Fairall L, Williams KJ, Song W, Munguia P, Russell RA, Martin MG, Jung ME, Jiang H, Schwabe JWR, Young SG, Tontonoz P. Aster-dependent nonvesicular transport facilitates dietary cholesterol uptake. Science. 2023 Nov 10;382(6671):eadf0966. doi: 10.1126/science.adf0966. Epub 2023 Nov 10. PMID: 37943936; PMCID: PMC11073449.
Hornburg D, Wu S, Moqri M, Zhou X, Contrepois K, Bararpour N, Traber GM, Su B, Metwally AA, Avina M, Zhou W, Ubellacker JM, Mishra T, Schüssler-Fiorenza Rose SM, Kavathas PB, Williams KJ, Snyder MP. Dynamic lipidome alterations associated with human health, disease and ageing. Nat Metab. 2023 Sep;5(9):1578-1594. doi: 10.1038/s42255-023-00880-1. Epub 2023 Sep 11. PMID: 37697054; PMCID: PMC10513930.
Almoughrabie S, Cau L, Cavagnero K, O'Neill AM, Li F, Roso-Mares A, Mainzer C, Closs B, Kolar MJ, Williams KJ, Bensinger SJ, Gallo RL. Commensal Cutibacterium acnes induce epidermal lipid synthesis important for skin barrier function. Sci Adv. 2023 Aug 18;9(33):eadg6262. doi: 10.1126/sciadv.adg6262. Epub 2023 Aug 18. PMID: 37595033; PMCID: PMC10438445.
Minami JK, Morrow D, Bayley NA, Fernandez EG, Salinas JJ, Tse C, Zhu H, Su B, Plawat R, Jones A, Sammarco A, Liau LM, Graeber TG, Williams KJ, Cloughesy TF, Dixon SJ, Bensinger SJ, Nathanson DA. CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis. Cancer Cell. 2023 Jun 12;41(6):1048-1060.e9. doi: 10.1016/j.ccell.2023.05.001. Epub 2023 May 25. PMID: 37236196; PMCID: PMC10330677.
Eyme KM, Sammarco A, Jha R, Mnatsakanyan H, Pechdimaljian C, Carvalho L, Neustadt R, Moses C, Alnasser A, Tardiff DF, Su B, Williams KJ, Bensinger SJ, Chung CY, Badr CE. Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblastoma mouse models. Sci Transl Med. 2023 Jan 18;15(679):eabq6288. doi: 10.1126/scitranslmed.abq6288. Epub 2023 Jan 18. PMID: 36652537; PMCID: PMC9942236.
Magtanong L, Mueller GD, Williams KJ, Billmann M, Chan K, Armenta DA, Pope LE, Moffat J, Boone C, Myers CL, Olzmann JA, Bensinger SJ, Dixon SJ. Context-dependent regulation of ferroptosis sensitivity. Cell Chem Biol. 2022 Oct 20;29(10):1568. doi: 10.1016/j.chembiol.2022.08.008. Erratum for: Cell Chem Biol. 2022 Sep 15;29(9):1409-1418.e6. doi: 10.1016/j.chembiol.2022.06.004. PMID: 36270234.
Ghorasaini M, Mohammed Y, Adamski J, Bettcher L, Bowden JA, Cabruja M, Contrepois K, Ellenberger M, Gajera B, Haid M, Hornburg D, Hunter C, Jones CM, Klein T, Mayboroda O, Mirzaian M, Moaddel R, Ferrucci L, Lovett J, Nazir K, Pearson M, Ubhi BK, Raftery D, Riols F, Sayers R, Sijbrands EJG, Snyder MP, Su B, Velagapudi V, Williams KJ, de Rijke YB, Giera M. Cross-laboratory standardization of preclinical lipidomics using differential mobility spectrometry and multiple reaction monitoring. Anal Chem. 2021 Dec 14;93(49):16369-16378. doi: 10.1021/acs.analchem.1c02826. Epub 2021 Dec 3. PMID: 34859676; PMCID: PMC8674878.
Flores YN, Amoon AT, Su B, Velazquez-Cruz R, Ramírez-Palacios P, Salmerón J, Rivera-Paredez B, Sinsheimer JS, Lusis AJ, Huertas-Vazquez A, Saab S, Glenn BA, May FP, Williams KJ, Bastani R, Bensinger SJ. Serum lipids are associated with nonalcoholic fatty liver disease: a pilot case-control study in Mexico. Lipids Health Dis. 2021 Oct 10;20(1):136. doi: 10.1186/s12944-021-01526-5. PMID: 34629052; PMCID: PMC8504048.
Su B, Bettcher LF, Hsieh WY, Hornburg D, Pearson MJ, Blomberg N, Giera M, Snyder MP, Raftery D, Bensinger SJ, Williams KJ. A DMS shotgun lipidomics workflow application to facilitate high-throughput, comprehensive lipidomics. J Am Soc Mass Spectrom. 2021 Nov 3;32(11):2655-2663. doi: 10.1021/jasms.1c00203. Epub 2021 Oct 12. PMID: 34637296; PMCID: PMC8985811.
Salisbury DA, Casero D, Zhang Z, Wang D, Kim J, Wu X, Vergnes L, Mirza AH, Leon-Mimila P, Williams KJ, Huertas-Vazquez A, Jaffrey SR, Reue K, Chen J, Sallam T. Transcriptional regulation of N6-methyladenosine orchestrates sex-dimorphic metabolic traits. Nat Metab. 2021 Jul;3(7):940-953. doi: 10.1038/s42255-021-00427-2. Epub 2021 Jul 19. Erratum in: Nat Metab. 2022 Jul;4(7):960. doi: 10.1038/s42255-022-00614-9. Erratum in: Nat Metab. 2023 Mar;5(3):530. doi: 10.1038/s42255-023-00748-4. PMID: 34282353; PMCID: PMC8422857.
Clifford BL, Sedgeman LR, Williams KJ, Morand P, Cheng A, Jarrett KE, Chan AP, Brearley-Sholto MC, Wahlström A, Ashby JW, Barshop W, Wohlschlegel J, Calkin AC, Liu Y, Thorell A, Meikle PJ, Drew BG, Mack JJ, Marschall HU, Tarling EJ, Edwards PA, de Aguiar Vallim TQ. FXR activation protects against NAFLD via bile-acid-dependent reductions in lipid absorption. Cell Metab. 2021 Aug 3;33(8):1671-1684.e4. doi: 10.1016/j.cmet.2021.06.012. Epub 2021 Jul 15. PMID: 34270928; PMCID: PMC8353952.
Anastasia I, Ilacqua N, Raimondi A, Lemieux P, Ghandehari-Alavijeh R, Faure G, Mekhedov SL, Williams KJ, Caicci F, Valle G, Giacomello M, Quiroga AD, Lehner R, Miksis MJ, Toth K, de Aguiar Vallim TQ, Koonin EV, Scorrano L, Pellegrini L. Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis. Cell Rep. 2021 Mar 16;34(11):108873. doi: 10.1016/j.celrep.2021.108873. PMID: 33730569.
Middlekauff HR, William KJ, Su B, Haptonstall K, Araujo JA, Wu X, Kim J, Sallam T. Changes in lipid composition associated with electronic cigarette use. J Transl Med. 2020 Oct 7;18(1):379. doi: 10.1186/s12967-020-02557-9. PMID: 33028369; PMCID: PMC7542424.
Hsieh WY, Zhou QD, York AG, Williams KJ, Scumpia PO, Kronenberger EB, Hoi XP, Su B, Chi X, Bui VL, Khialeeva E, Kaplan A, Son YM, Divakaruni AS, Sun J, Smale ST, Flavell RA, Bensinger SJ. Toll-like receptors induce signal-specific reprogramming of the macrophage lipidome. Cell Metab. 2020 Jul 7;32(1):128-143.e5. doi: 10.1016/j.cmet.2020.05.003. Epub 2020 Jun 8. PMID: 32516576; PMCID: PMC7891175.
Zhou QD, Chi X, Lee MS, Hsieh WY, Mkrtchyan JJ, Feng AC, He C, York AG, Bui VL, Kronenberger EB, Ferrari A, Xiao X, Daly AE, Tarling EJ, Damoiseaux R, Scumpia PO, Smale ST, Williams KJ, Tontonoz P, Bensinger SJ. Interferon-mediated reprogramming of membrane cholesterol to evade bacterial toxins. Nat Immunol. 2020 Jul;21(7):746-755. doi: 10.1038/s41590-020-0695-4. Epub 2020 Jun 8. PMID: 32514064; PMCID: PMC7778040.
Williams KJ, Bensinger SJ. Cellular fatty acid analysis in macrophage using stable isotope labeling. Methods Mol Biol. 2020;2184:47-60. doi: 10.1007/978-1-0716-0802-9_4. PMID: 32808217.
Zhang Z, Feng AC, Salisbury D, Liu X, Wu X, Kim J, Lapina I, Wang D, Lee B, Fraga J, Pan C, Williams KJ, Lusis AJ, Scumpia P, Sallam T. Collaborative interactions of heterogenous ribonucleoproteins contribute to transcriptional regulation of sterol metabolism in mice. Nat Commun. 2020 Feb 20;11(1):984. doi: 10.1038/s41467-020-14711-4. PMID: 32080181; PMCID: PMC7033216.
Hsieh WY, Williams KJ, Su B, Bensinger SJ. Profiling of mouse macrophage lipidome using direct infusion shotgun mass spectrometry. STAR Protoc. 2020 Dec 19;2(1):100235. doi: 10.1016/j.xpro.2020.100235. PMID: 33364623; PMCID: PMC7753944.
Leung KL, Sanchita S, Pham CT, Davis BA, Okhovat M, Ding X, Dumesic P, Grogan TR, Williams KJ, Morselli M, Ma F, Carbone L, Li X, Pellegrini M, Dumesic DA, Chazenbalk GD. Dynamic changes in chromatin accessibility, altered adipogenic gene expression, and total versus de novo fatty acid synthesis in subcutaneous adipose stem cells of normal-weight polycystic ovary syndrome (PCOS) women during adipogenesis: evidence of cellular programming. Clin Epigenetics. 2020 Nov 23;12(1):181. doi: 10.1186/s13148-020-00970-x. PMID: 33228780; PMCID: PMC7686698.
Argus JP, Wilks MQ, Zhou QD, Hsieh WY, Khialeeva E, Hoi XP, Bui V, Xu S, Yu AK, Wang ES, Herschman HR, Williams KJ, Bensinger SJ. Development and Application of FASA, a Model for Quantifying Fatty Acid Metabolism Using Stable Isotope Labeling. Cell Rep. 2018 Dec 4;25(10):2919-2934.e8. doi: 10.1016/j.celrep.2018.11.041. PMID: 30517876; PMCID: PMC6432944.

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